何延红

教授、博士生导师

个人简介

1966年生于云南西双版纳，云南大学学士学位（1988），云南省热带作物科学研究所助理研究员（1988-1996），中山大学有机化学硕士学位（1999，导师：曾陇梅教授），中山大学化学与化学工程学院讲师（1999.06-2001.02），瑞典隆德（Lund）大学有机化学博士学位（2004.11，导师：Olov Sterner教授），伟德手机版APP|中国有限公司任教（2005至今）。先后主持国家自然科学基金面上项目2项、应急管理项目1项，重庆市自然科学基金重点项目1项、一般项目1项，教育部留学回国人员科研启动基金1项，重庆市人事局留学回国人员科技活动择优项目1项。迄今, 在《Angew. Chem. Int. Ed.》、《Org. Lett.》、《Chem. Commun.》、《Adv. Synth. Catal.》、《Green Chem.》、《ChemSusChem》、《J. Org. Chem.》等国际学术刊物上发表SCI收录论文100余篇；获授权发明专利24项；科研成果获重庆市2015年度自然科学二等奖（排名第二）。研究工作两次被美国《化学与工程新闻》（Chemical & Engineering News，C&EN）报道。

联系方式

手机：13647670859

E-mail：heyh@swu.edu.cn

研究方向

酶催化的有机合成、光氧化还原催化和电化学促进的自由基反应研究。

代表性论文

[1]   Xuan Ding, Chun-Lin Dong, Zhi Guan*, Yan-Hong He*. Concurrent asymmetric reactions combining photocatalysis and enzymatic catalysis: direct enantioselective synthesis of 2,2-disubstituted indol-3-ones from 2-arylindoles. Angew. Chem. Int. Ed., 2019, 58(1), 118-124. Hot Paper

[2]   Chun-Lin Dong, Xuan Ding, Lan-Qian Huang, Yan-Hong He*, Zhi Guan*. Merging visible light photocatalysis and L-/D-proline catalysis: direct asymmetric oxidative dearomatization of 2-arylindoles to access C2-quaternary indolin-3-ones. Org. Lett., 2020, 22(3), 1076-1080.

[3]   Fo-Yun Lu, Yu-Jue Chen, Yuan Chen, Xuan Ding, Zhi Guan*, Yan-Hong He*. Highly enantioselective electrosynthesis of C2-quaternary indolin-3-ones. Chem. Commun., 2020, 56(4), 623-626.

[4]   Jie Chen, Zoe G. Allyson, Jing-Rui Xin, Zhi Guan*, Yan-Hong He*. Photo-mediated decarboxylative ketonization of atropic acids with sulfonyl hydrazides: direct access to β-ketosulfones. Adv. Synth. Catal., 2020, 362(10), 2045-2051.

[5]   Yu-Jue Chen, Guo-Yan Zhang, Yan-Hong He*, Zhi Guan*. Aryl C-H amination initiated by laccase-mediated oxidation of 4-phenylurazole. Catal. Sci. Technol., 2019, 9(16), 4216-4221.  

2019 Hot Catalysis Science & Technology Article

[6]   Li Tang, Jack H. Matuska, Yu-Han Huang, Yan-Hong He,* Zhi Guan*. Amide synthesis from thiocarboxylic acids and amines by spontaneous reaction and electrosynthesis. ChemSusChem, 2019, 12(12), 2570-2575.

[7]   Li Tang, Xing-Meng Li, Jack H. Matuska, Yan-Hong He,* and Zhi Guan*. Intramolecular transamidation of secondary amides via visible light induced tandem reaction. Org. Lett., 2018, 20 (18), 5618-5621.

[8]   Wei Zhang, Gabriel M. Johnson, Zhi Guan*, Yan-Hong He*. Regio- and tereoselective hydrosulfonylation of electron-deficient alkynes: access to both E- and Z-β-sulfonyl-α,β-unsaturated carbonyl compounds. Adv. Synth. Catal., 2018, 360(23), 4562-4570.

[9]   Xuan Ding, Chun-Lin Dong, Zhi Guan*, Yan-Hong He*. Visible-light-promoted alkylation of indoles with tertiary amines by the oxidation of a sp³ C-H bond. Adv. Synth. Catal., 2018, 360(4), 762-767.

[10] Jing-Rui Xin, Yan-Hong He*, Zhi Guan*, Metal-free aerobic oxidative direct C-H amination of electron-deficient alkenes via photoredox catalysis. Org. Chem. Front., 2018, 5(10), 1684-1688.

[11] Guo-Yan Zhang, Yang Xiang, Zhi Guan*, Yan-Hong He*. Enzyme and photoredox sequential catalysis for the synthesis of 1,3-oxazine derivatives in one pot. Catal. Sci. Technol., 2017, 7(9), 1937-1942.

[12] Jun-Tao Guo, Da-Cheng Yang, Zhi Guan*, Yan-Hong He*. Chlorophyll-catalyzed visible-light-mediated synthesis of tetrahydroquinolines from N,N-dimethylanilines and maleimides. J. Org. Chem., 2017, 82(4), 1888-1894. Featured Article, ACS Editors' Choice

[13] Yan-Hong He*, Yang Xiang, Da-Cheng Yang, Zhi Guan*. Combining enzyme and photoredox catalysis for aminoalkylation of indoles via a relay catalysis strategy in one pot. Green Chem., 2016, 18(19), 5325-5330.

[14] Yang Xiang, Jian Song, Yong Zhang, Da-Cheng Yang, Zhi Guan*, Yan-Hong He* Enzyme-catalyzed asymmetric domino thia-Michael/aldol condensation using pepsin. J. Org. Chem., 2016, 81(14), 6042-6048.

[15] Ling-Ling Wu, Yang Xiang, Da-Cheng Yang, Zhi Guan* and Yan-Hong He*. Biocatalytic asymmetric Mannich reaction of ketimines using wheat germ lipase. Catal. Sci. Technol., 2016, 6(11), 3963-3970.

[16] Ling-Po Li, Xin Cai, Yang Xiang, Yong Zhang, Jian Song, Da-Cheng Yang, Zhi Guan* Yan-Hong He*. The α-chymotrypsin-catalyzed Povarov reaction: one-pot synthesis of tetrahydroquinoline derivatives. Green Chem., 2015, 17(5), 3148-3156.

[17] Yuan Yi, Guan Zhi*, He Yan Hong*. Biocatalytic direct asymmetric aldol reaction using proteinase from Aspergillus melleus. Sci. China Chem., 2013, 56(7), 939-944.

[18] Yan-Hong He, Hai-Hong Li, Yan-Li Chen, Yang Xue, Yi Yuan, Zhi Guan*. Chymopapain-catalyzed direct asymmetric aldol reaction. Adv. Synth. Catal., 2012, 354(4), 712-719.

[19] Yan-Hong He*, Wen Hu, Zhi Guan*. Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using hen egg white lysozyme. J. Org. Chem., 2012, 77(1), 200-207.

[20] Chang-Heng Wang, Zhi Guan, Yan-Hong He*. Biocatalytic domino reaction: synthesis of 2H-1-benzopyran-2-one derivatives using alkaline protease from Bacillus licheniformis. Green Chem., 2011, 13(8), 2048 -2054.